In Skeletal Muscle Depolarization of the T Tubule Membrane Causes

Question

In skeletal muscle depolarization of the T tubule membrane causes A) activation of Ca²⁺ ATPase pumps which triggers a rise in intracellular calcium levels B) dihydropyridine to bind calcium channel receptors which triggers a rise in intracellular calcium levels. C) activation of stretch-activated Ca²⁺channels which triggers a rise in intracellular calcium levels. D) activation of dihydroxypyridine receptors in membrane of the T tubule which triggers a rise in intracellular calcium levels. E) ryanodine to bind calcium channel receptors which triggers a rise in intracellular calcium levels.

Accepted Answer

Depolarization of the T tubule membrane in skeletal muscle activates dihydropyridine receptors, which are voltage-sensitive and located in the T tubule membrane. This activation leads to a conformational change that triggers the opening of ryanodine receptors in the sarcoplasmic reticulum, resulting in a rise in intracellular calcium levels.