From the list provided, select all that can be inferred from the given sample pedigree for sickle-cell disease. (Check all that apply.) 11ee40c6_1829_d115_b977_fbe2042b1725

A) Both parents in the first generation are carriers of sickle-cell disease, but do not have the disease.
B) In the second generation, there are no offspring who carry the allele for sickle-cell disease.
C) Sickle-cell disease is a recessive disease.
D) Both parents must be homozygous recessive to produce offspring with sickle-cell disease.
E) In the second generation, only one offspring has sickle-cell disease.