A biological reaction with a significantly postive ΔG under cellular conditions may proceed in the forward direction because

A) The cell will change the concentrations of the substrates and products so that the reaction can occur
B) The cell will raise the temperature, thereby affecting the overall thermodynamics of the reaction
C) the reaction can be coupled to a reaction with a more significant negative ΔG
D) reactions with positive ΔG values always proceed in the forward direction
E) None of these