Why did the drug-related mortality rate for White people in the US with a high school degree or less increase so dramatically in the mid-late 2000s and the 2010s?

A) They are genetically inclined toward drug abuse
B) They are more prone, biologically, to heart attacks from opioids than other populations
C) The law was much stricter with White drug users and this resulted in reliance on illegal drugs instead of doctor-prescribed pharmaceuticals
D) Actually, this increase was seen in Whites with more education, not those with less
E) This population's high expectations for a middle-class lifestyle were dashed by deindustrialization and the resulting despair that many felt fueled an epidemic of addiction