Stargazin is Critical to the Trapping of AMPA Receptors in the PSD

Question

Stargazin is critical to the trapping of AMPA receptors in the PSD.

Accepted Answer

Stargazin binds to the AMPA receptor and anchors it to the postsynaptic density (PSD), thereby playing a critical role in the clustering and stabilization of AMPA receptors at the synapse. Without stargazin, AMPA receptors are more mobile and can diffuse away from the synapse, leading to a decrease in synaptic strength.