Antagonizing NMDA Receptor After LTP is Established Prevents LTP Expression

Question

Antagonizing NMDA receptor after LTP is established prevents LTP expression.

Accepted Answer

Once LTP (Long-Term Potentiation) is established, it involves structural changes at the synapse, making it less susceptible to disruption by antagonizing NMDA receptors, which are more critical for the induction phase of LTP rather than its maintenance or expression.