Sequence Differences Between Homologues are Greater Than Between Sister Chromatids

Question

Sequence differences between homologues are greater than between sister chromatids.

Accepted Answer

Sister chromatids differ only as a result of the last round of replication, so differences between them are minimal (a few base pairs difference). Differences between homologues vary depending on their evolutionary history, but are in the region of 250,000 base pairs (approximately 0.1%).