Unlike Most Steroid-Based Hormones, How Will Protein Hormones Typically Work

Question

Unlike most steroid-based hormones, how will protein hormones typically work?
A) by binding to receptors on the surface of target cells
B) by binding to receptors inside the target cells
C) by binding to receptors in the nucleus of target cells
D) by causing target cells to turn specific genes on and off

Accepted Answer

Protein hormones typically cannot cross the plasma membrane of target cells because they are hydrophilic. Therefore, they bind to receptors on the surface of target cells to initiate intracellular signaling cascades.