Select the Pathway That Would Lead to the Activation of B

Question

Select the pathway that would lead to the activation of B cells in the humoral immune response.
A)B cell internalizes antigen → helper T cell binds to class II MHC molecule-antigen complex → B cell proliferates and differentiates → activated helper T cell binds to B cell and releases cytokines
B)self-tolerance of immune cells → B cells contact antigen → cytokines released
C)complement is secreted → B cell contacts antigen → helper T cell activated → cytokines released
D)B cell internalizes antigen → class II MHC molecule-antigen complex displayed→ activated helper T cell binds to B cell and releases cytokines → B cell proliferates and differentiates
E)natural killer cells → class II MHC molecule-antigen complex displayed → cytokines released → cell lysis

Accepted Answer

The pathway that would lead to the activation of B cells in the humoral immune response is B cell internalizes antigen → class II MHC molecule-antigen complex displayed→ activated helper T cell binds to B cell and releases cytokines → B cell proliferates and differentiates. This is because B cells require T cell help to become activated and differentiate into antibody-secreting plasma cells. The helper T cell recognizes the antigen presented by the B cell through the class II MHC molecule and releases cytokines to stimulate B cell proliferation and differentiation.