B Cells Interacting with Helper T Cells are Stimulated to Differentiate

Question

B cells interacting with helper T cells are stimulated to differentiate when
A)B cells produce IgE antibodies.
B)B cells release cytokines.
C)helper T cells present the class II MHC molecule-antigen complex on their surface.
D)helper T cells differentiate into cytotoxic T cells.
E)helper T cells release cytokines.

Accepted Answer

Helper T cells stimulate B cell differentiation through the release of cytokines, such as interleukin-4 (IL-4) and interleukin-21 (IL-21). These cytokines bind to receptors on the surface of the B cell and induce their differentiation into antibody-secreting plasma cells or memory B cells. Choice A is incorrect because IgE antibodies are not involved in the initial differentiation of B cells. Choice B is partially correct, as B cells do release cytokines, but this is not what stimulates their differentiation. Choice C is incorrect because it describes the initial activation of the helper T cell, not the stimulation of the B cell. Choice D is incorrect because cytotoxic T cells do not interact with B cells in this manner.