What is an Early Step in Shotgun Sequencing

Question

What is an early step in shotgun sequencing?
A)break genomic DNA at random sites
B)map the position of cloned DNA fragments
C)randomly select DNA primers and hybridize these to random positions of chromosomes in preparation for sequencing
D)sequence fragments

Accepted Answer

The first step in shotgun sequencing is to break the genomic DNA into random fragments. This is usually done using physical or chemical methods, such as sonication or restriction enzymes. Only option A mentions this step. The other options describe later steps in the process.