For Which of the Following Might RNAi More Possibly Be

Question

For which of the following might RNAi more possibly be useful?
A)to raise the rate of production of a needed digestive enzyme
B)to decrease the production from a harmful gain-of-function mutated gene
C)to destroy an unwanted allele in a homozygous individual
D)to form a knockout organism that will not pass the deleted sequence to its progeny
E)to raise the concentration of a desired protein

Accepted Answer

RNAi is a process of post-transcriptional gene silencing, which can reduce or eliminate the expression of a gene. Therefore, it could be used to decrease the production of a harmful gene, like a gain-of-function mutated gene. It is not typically used to increase production, as in choice A, or to destroy an unwanted allele, as in choice C. While it can be used to increase the concentration of a protein, as in choice E, this is not the most likely scenario presented. Choice D is not related to the question prompt.