Use the following information to answer the next few questions.
Poliovirus is a positive-sense RNA virus of the picornavirus group.At its 5' end,the RNA genome has a viral protein (VPg)instead of a 5' cap.This is followed by a nontranslated leader sequence,and then a single long protein coding region (~7000 nucleotides),followed by a poly-A tail.Observations were made that used radioactive amino acid analogues.Short-period use of the radioactive amino acids result in labelling of only very long proteins,while longer periods of labelling result in several different short polypeptides.
-What part of the poliovirus would first interact with host cell ribosomes to mediate translation?
A)the poly-A tail
B)the leader sequence
C)the VPg protein
D)the AUG in the leader sequence
E)the AUG at the start of the coding sequence