Only Once All Kinetochores are Attached to Spindle Microtubules Can

Question

Only once all kinetochores are attached to spindle microtubules can ________ proceed.
A)metaphase
B)anaphase
C)synthesis
D)MPF
E)G₀

Accepted Answer

Anaphase cannot occur until all kinetochores are attached to spindle microtubules. This ensures that each chromosome will be properly segregated to each daughter cell. Metaphase can begin once the chromosomes have aligned at the metaphase plate, but anaphase cannot begin until all kinetochores are attached. Synthesis (DNA replication) and G₀ are not part of the mitotic process. MPF, or the mitotic checkpoint complex, is responsible for ensuring that all kinetochores are properly attached before allowing anaphase to proceed.