Which of the following statements regarding enzymes is true?

A)Enzymes increase the rate of a reaction by making the reaction more exergonic.
B)Enzymes increase the rate of a reaction by lowering the activation energy barrier.
C)Enzymes increase the rate of a reaction by reducing the rate of reverse reactions.
D)Enzymes change the equilibrium point of the reactions they catalyze.
E)Enzymes make the rate of a reaction independent of substrate concentrations.