Coreceptor Inhibitors Block HIV Infection by Preventing Which of the Following

Question

Coreceptor inhibitors block HIV infection by preventing which of the following?
A) binding of the HIV virion onto the plasma membrane
B) binding of the HIV virion onto the CCR5 receptor
C) binding of the HIV virion onto the gp120 protein
D) degrading the coreceptor so the virion cannot attach
E) binding of the HIV virion onto the CD4 receptor

Accepted Answer

Coreceptor inhibitors, such as maraviroc, prevent HIV infection by binding to the CCR5 receptor on the surface of CD4+ T cells, macrophages, and dendritic cells. This prevents the HIV virion from binding to the CCR5 receptor and entering the host cell, effectively blocking the first step of the viral replication cycle.