Deficiency of _______ Causes Lesch-Nyhan Syndrome

Question

Deficiency of _______ causes Lesch-Nyhan syndrome.
A) Folic acid
B) Carbamoyl phosphate synthetase II
C) UMP synthase
D) HGPRT
E) Mg-Protoporphyrin methylesterase

Accepted Answer

Lesch-Nyhan syndrome is caused by a deficiency of the enzyme Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), which is crucial for purine metabolism.