Examples of Uncouplers Include __________

Question

Examples of uncouplers include __________.
A) DNP
B) antimycin
C) gramicidin
D) Both A and B are correct.
E) Both A and C are correct.

Accepted Answer

Uncouplers disrupt the proton gradient across the mitochondrial membrane, which is essential for ATP synthesis. DNP (2,4-Dinitrophenol) and gramicidin are examples of such uncouplers. DNP carries protons across the mitochondrial membrane, while gramicidin forms channels that allow ions to pass through, both disrupting the proton gradient. Antimycin, on the other hand, is an inhibitor of the electron transport chain, not an uncoupler.