The Expression of the Michaelis Constant is Equal To

Question

The expression of the Michaelis constant is equal to
A) (K2+ K3)/K1
B) (K2+ K1./K3
C) (K1+ K2)/K3
D) (K3+ K1) + K3
E) (K2/K1) + K3
Where
K1= the rate constant for ES formation
K2= the rate constant for ES dissociation
K3= the rate constant for product formation

Accepted Answer

The Michaelis constant (K_m) is a measure of the affinity of an enzyme for its substrate. It is defined as the substrate concentration at which the reaction rate is half of the maximum rate. The Michaelis constant can be expressed in terms of the rate constants for the individual steps of the reaction. The correct answer is A, (K₂ + K₃)/K₁. This expression represents the ratio of the rate constants for ES dissociation and product formation to the rate constant for ES formation.