Which of the following is most likely to occur when a tumor-suppressor gene is mutated,resulting in cancer?

A)The resulting tumor-suppressor protein will be overexpressed.
B)The resulting tumor-suppressor protein would further suppress cell proliferation.
C)The resulting tumor-suppressor protein would activate an oncogene.
D)The resulting tumor-suppressor protein would lose its ability to suppress cell proliferation.
E)None of the choices are possiblE.