Which of the following is true regarding maternal-effect genes?

A) Bicoid and Nanos are maternal-effect genes.
B) A female homozygous for a loss-of-function maternal-effect gene mutation can be fully normal, but her offspring will show the phenotype.
C) The offspring of a female homozygous for a loss-of-function maternal-effect gene mutation will show the phenotype regardless of the paternal genotype.
D) The second-generation offspring of a male homozygous for a loss-of-function maternal-effect gene mutation can show the phenotype.
E) All of the above.