Indicate true (T) and false (F) statements below regarding cancer. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( ) Cancers become less and less heterogeneous as they progress.
( ) Knocking out Ras or Myc genes individually leads to a higher incidence of cancers in mice, and knocking out both genes simultaneously has an even stronger phenotype.
( ) Wnt signaling is important in colon epithelial cells and, correspondingly, mutations in genes in the Wnt pathway are present in most colorectal cancers.
( ) Genome destabilization in a subset of colorectal cancers that have defects in DNA mismatch repair takes the form of chromosome breaks, translocations, and deletions.