Indicate true (T) and false (F) statements below regarding the mutational landscape of cancer cells. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( ) In each cancer, usually there is one driver mutation and a large number of passenger mutations.
( ) It is estimated that about 20% of our genes are cancer-critical.
( ) Cancer-critical genes can encode metabolic enzymes or components of the RNA splicing machinery.
( ) The karyotype is often severely disordered in cancer cells.