Indicate true (T) and false (F) statements below regarding cellular control of growth and division. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTF.
( ) Replicative cell senescence usually arises due to the accumulation of mutations in genes encoding S- and M-cyclins.
( ) Replicative cell senescence is caused by the induction of apoptosis by p53.
( ) Excessive mitogenic stimulation can result in Mdm2 activation and the induction of apoptosis or cell-cycle arrest.
( ) The Mdm2 inhibitor Arf induces cell-cycle progression.