Which of the following events contributes to driving the mammalian cell past the restriction point of the cell cycle?

A) Phosphorylation of Cdh1-APC/C by G₁/S-Cdk
B) Destruction of CKIs that target S-Cdks
C) Phosphorylation of Rb by G₁-Cdk, G₁/S-Cdk, and S-Cdk
D) Activation of E2F gene expression by active E2F protein
E) All of the above