During Maturation of Early Endosomes to Late Endosomes, …

Question

During maturation of early endosomes to late endosomes, …
A) the vacuolar domain of the endosome is shed, whereas the tubular domain is retained.
B) the endosome migrates along actin filaments away from the cell interior.
C) the lumen of the endosome becomes more acidic.
D) intralumenal vesicles disappear.
E) All of the above.

Accepted Answer

During maturation, the endosome sheds its tubular domains and retains its vacuolar domains, the lumen of which becomes more acidic. The endosome moves along microtubule tracks toward the cell interior, and acquires intralumenal vesicles for membrane protein degradation. It also receives new components from the trans Golgi network.