Which of the following changes is more likely to further confine a membrane protein within a corral established by the cortical cytoskeletal network?

A) Increased temperature
B) Protease cleavage of the extracellular domain of the protein
C) Binding to an extracellular ligand
D) Protease cleavage of the cytosolic domain of the protein
E) Binding of the protein to other transmembrane proteins