When unfolded proteins accumulate in the lumen of the endoplasmic reticulum due to inefficient folding conditions, a membrane-bound protein kinase is activated and phosphorylates a subunit of the translation initiation factor eIF2. Indicate which of the following events would (Y) or would not (N) occur as a result. Your answer would be a four-letter string composed of letters Y and N only, e.g. YYYY.
( ) eIF2 binds tightly to the ribosome.
( ) Translation initiation is stimulated.
( ) The GDP-bound form of eIF2 accumulates.
( ) eIF2B is activated.