Question 37

(Short Answer)

In the following pedigree, females and males are indicated by circles and squares, respectively, and the presence of a rare disease caused by a loss-of-function mutation in an imprinted autosomal gene is indicated by black color. Is the gene maternally imprinted (M; i.e. not expressed from the maternally inherited chromosome) or paternally imprinted (P)? Write down M or P as your answer.
In the following pedigree, females and males are indicated by circles and squares, respectively, and the presence of a rare disease caused by a loss-of-function mutation in an imprinted autosomal gene is indicated by black color. Is the gene maternally imprinted (M; i.e. not expressed from the maternally inherited chromosome) or paternally imprinted (P)? Write down M or P as your answer.

Answer

If a disease-causing gene is ...

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