Which of the Following is NOT Correct Regarding Homologous Recombination

Question

Which of the following is NOT correct regarding homologous recombination and its regulation?
A) Loss of heterozygosity can occur if a broken chromosome is repaired using a sister chromatid instead of its homologous chromosome.
B) Repair of double-strand breaks by homologous recombination is favored during or soon after DNA replication.
C) Homologous recombination can rescue broken or stalled replication forks in S phase.
D) Excessive use of homologous recombination by human cells can lead to cancer.
E) Low usage of homologous recombination by human cells can lead to cancer.

Accepted Answer

If a homologous chromosome is used (instead of a sister chromatid) to repair a double-strand break, one of the parental alleles of the affected gene can be replaced by the other allele, leading to loss of heterozygosity.