Which of the Following Spontaneous Lesions in DNA Occurs Most

Question

Which of the following spontaneous lesions in DNA occurs most frequently in a mammalian cell?
A) Depurination
B) Cytosine deamination
C) Guanine oxidation
D) Guanine alkylation
E) Depyrimidination

Accepted Answer

Depurination (that is, the hydrolytic removal of purine bases from DNA) is by far the most common endogenous DNA lesion in our cells. Please refer to Table 5-3 for details.