Question 5

(Multiple Choice)

At the replication fork, the template for the lagging strand is thought to loop around. This looping would allow the lagging-strand polymerase to move along with the rest of the replication fork instead of in the opposite direction. The single-strand part of the loop is bound by the single-strand DNA-binding (SSB) proteins. As each Okazaki fragment is synthesized toward completion, how does the size of the loop change? What about the size of the SSB-bound part of the loop?


A) Increases; increases.
B) Increases; decreases.
C) Decreases; increases.
D) Decreases; decreases.
E) Decreases; does not change.

Answer