During DNA Replication, the Single-Strand DNA-Binding (SSB) Proteins …

Question

During DNA replication, the single-strand DNA-binding (SSB) proteins …
A) are generally found more on the leading strand than the lagging strand.
B) bind cooperatively to single-stranded DNA and cover the bases to prevent base-pairing.
C) prevent the folding of the single-stranded DNA.
D) bind cooperatively to short hairpin helices that readily form in the single-stranded DNA.
E) All of the above.

Accepted Answer

The SSB proteins bind cooperatively to the regions of exposed single-stranded DNA (which are routinely found in the lagging strand) and prevent the formation of hairpin helices without blocking the base-pairing potential.