Which of the following is correct regarding the mutation rate of genomic DNA in different organisms?

A) Human cells have a much higher mutation rate compared to bacteria when the rate is normalized to a single round of replication over the same length of DNA.
B) Mutation rates limit the number of essential genes in an organism's genome.
C) Mutations in the somatic cells cannot be lethal.
D) Even if the mutation rate was 10 times higher than its current value, germ-cell stability in humans would not have been affected.
E) All of the above.