How Do Multienzyme Complexes in the Cell, Such as the Fatty

Question

How do multienzyme complexes in the cell, such as the fatty acid synthase, enhance reaction rates?
A) By increasing the diffusion rate of their substrate in the cell
B) By allowing the channeling of pathway intermediates from one enzyme to the next
C) By limiting the diffusion of the substrates in membrane-bound compartments
D) By increasing the intrinsic rate of catalysis for individual enzymes
E) All of the above

Accepted Answer

When the diffusion of substrates is limiting the overall rate of an enzymatic reaction or pathway, the use of multienzyme complexes enhances the rate by bringing the various enzymes together and passing the pathway intermediates between them.