Enzymes can catalyze cellular reactions through various mechanisms. Which of the following statements is NOT true regarding enzymes?

A) They can provide the chemical groups necessary for simultaneous acid and base catalysis.
B) They have a higher affinity for the transition state of the substrate than for its stable form.
C) They can form covalent bonds with the substrate during catalysis.
D) They can strain a substrate to force it toward a specific transition state.
E) They accelerate a cellular reaction by destabilizing the transition state.