Infection with Some Salmonella Enterica Serotypes Can Progress to Typhoid

Question

Infection with some Salmonella enterica serotypes can progress to typhoid fever when the bacteria
A) attach to cells of the small intestine.
B) induce endocytosis by intestinal cells.
C) reproduce within cells of the small intestine.
D) produce type III secretion system proteins.
E) enter the blood and are engulfed by phagocytes.

Accepted Answer

Typhoid fever occurs when Salmonella enterica serotypes enter the bloodstream and are engulfed by phagocytes, allowing them to spread throughout the body, including to organs and tissues beyond the intestines. This systemic spread is what characterizes typhoid fever, distinguishing it from more localized gastrointestinal infections caused by other Salmonella serotypes.