Inhalation anthrax is frequently fatal even with antibiotic therapy because

A) Bacillus anthracis is resistant to a wide range of antibiotics.
B) it is transmitted as endospores.
C) the anthrax toxin triggers necrosis and severe edema of the lungs.
D) the bacteria are enclosed within a biofilm that antibiotics cannot penetrate.
E) the dying cells release lipid A, triggering a severe inflammatory response.