What is the Pathogenic Process Underlying Rocky Mountain Spotted Fever

Question

What is the pathogenic process underlying Rocky Mountain spotted fever?
A) cellular damage via potent exotoxins
B) damage to blood vessels
C) stimulation of a strong immune response
D) interference with host cell metabolism
E) formation of biofilms in host tissues

Accepted Answer

The pathogenic process underlying Rocky Mountain spotted fever involves damage to blood vessels, resulting in vascular leakage, tissue damage, and organ failure. This is caused by the bacteria invading endothelial cells lining blood vessels, leading to inflammation and microthrombi formation. This disrupts the blood supply to many organs, causing damage and dysfunction.