MHC Genes are Significant Genetic Factors in Predisposition to Develop

Question

MHC genes are significant genetic factors in predisposition to develop autoimmune disease.

Accepted Answer

MHC genes (major histocompatibility complex) are responsible for presenting antigens to the immune system for recognition and response. Variations or mutations in these genes can lead to the presentation of self-antigens, triggering an autoimmune response and predisposition to autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.