Which of the Following is the Mechanism of Action of Cyclosporine

Question

Which of the following is the mechanism of action of cyclosporine?
A) It blocks the complement cascade.
B) It blocks the activity of activated Th1 T cells.
C) It directly blocks CTL activity.
D) It interferes with activation of Th2 T cells.
E) It is an anti-inflammatory interfering with leukotriene function.

Accepted Answer

Cyclosporine blocks the activity of activated Th1 T cells by inhibiting the production of interleukin-2 (IL-2), a cytokine that is necessary for the activation and proliferation of T cells. This results in suppression of the immune response, which is useful in preventing transplant rejection and treating autoimmune diseases.