Which of the Following Antifungals Works by Binding to Ergosterol

Question

Which of the following antifungals works by binding to ergosterol in membranes?
A) fluconazole
B) turbinafine
C) amphotericin B
D) nystatin
E) both amphotericin B and nystatin

Accepted Answer

Both amphotericin B and nystatin work by binding to ergosterol in fungal cell membranes. This binding disrupts the integrity of the membrane, leading to cell death. Fluconazole and terbinafine work by inhibiting different enzymes involved in the synthesis of ergosterol, while nystatin and amphotericin B directly target ergosterol in the membrane.