Which of the Following Groups of Drugs Can Become Incorporated

Question

Which of the following groups of drugs can become incorporated into the bones and teeth of a fetus?
A) beta-lactams
B) aminoglycosides
C) quinolones
D) tetracyclines
E) sulfonamides

Accepted Answer

Tetracyclines can readily cross the placenta and accumulate in fetal bone and teeth, resulting in permanent discoloration of the teeth and possible bone growth abnormalities. It is contraindicated for use during pregnancy. The other drugs listed do not have significant uptake or accumulation in fetal bones or teeth.