Following the death of a patient with Alzheimer's disease, a neuropathologist examines several of her brain sections under the microscope. He notes a change in the cytoskeleton of several neurons. What is the most likely cause of this change?
A) Accumulation of tau protein B) Macrophage accumulation C) Increased synaptic activity D) Depletion of collagen fibers E) Protein depolymerization