Most Diuretics Increase Urine Production by Blocking the Effects of Which

Question

Most diuretics increase urine production by blocking the effects of which cation?
A) Calcium
B) Bicarbonate
C) Chloride
D) Sodium

Accepted Answer

Most diuretics increase urine production by blocking the effects of sodium reabsorption in the kidneys, leading to more sodium and water being excreted in the urine. This includes loop diuretics (such as furosemide), thiazide diuretics (such as hydrochlorothiazide), and potassium-sparing diuretics (such as spironolactone). Calcium, bicarbonate, and chloride do not play a significant role in the mechanism of action of diuretics.