Which of the Following is Most Likely to Cause Polyuria

Question

Which of the following is most likely to cause polyuria?
A) Oversecretion of aldosterone
B) Decreased glomerular filtration rate (GFR)
C) Deficiency of ADH
D) Activation of angiotensinogen

Accepted Answer

Polyuria is defined as excessive urine production. The deficiency of ADH (antidiuretic hormone) can cause polyuria because ADH plays an important role in regulating the body's water balance. When there is a deficiency of ADH, the kidneys are not able to reabsorb enough water, leading to the production of large amounts of dilute urine. Oversecretion of aldosterone (A) can cause excessive reabsorption of sodium, which in turn can increase water reabsorption, leading to decreased urine production. Decreased GFR (B) is associated with decreased urine production. Activation of angiotensinogen (D) results in the activation of the renin-angiotensin-aldosterone system, which can increase sodium and water reabsorption and decrease urine production.