Which of the Following Elicits the Same Effect as Vagomimetic

Question

Which of the following elicits the same effect as vagomimetic activity?
A) Beta1 blockade
B) Activation of the alpha1-adrenergic receptors by ACh
C) Activation of the muscarinic receptors by NE
D) Use of a muscarinic agonist

Accepted Answer

Vagomimetic activity refers to the activation of the parasympathetic nervous system, specifically the vagus nerve, which releases acetylcholine (ACh) to activate muscarinic receptors. Therefore, the best option that elicits the same effect as vagomimetic activity would be the use of a muscarinic agonist, which directly activates the same receptors that ACh would activate. Beta1 blockade (A) and activation of alpha1-adrenergic receptors by ACh (B) both involve activation of the sympathetic nervous system and have opposite effects to vagomimetic activity. Activation of muscarinic receptors by NE (C) would also have the opposite effect, as NE is typically released from sympathetic nerves, not parasympathetic ones.