Abrupt,sudden Withdrawal of Prednisone (Cortisol)is Most Likely to Cause

Question

Abrupt,sudden withdrawal of prednisone (cortisol)is most likely to cause
A) Cushing syndrome.
B) hypocalcemic tetany.
C) diabetes insipidus.
D) acute adrenal insufficiency.

Accepted Answer

Abrupt, sudden withdrawal of prednisone (cortisol) is most likely to cause acute adrenal insufficiency, also known as adrenal crisis. This occurs because prolonged use of glucocorticoids causes the adrenal glands to atrophy and become dependent on the external supply of the drug. Abrupt cessation of the drug can then result in a sudden drop in steroid hormone levels, leading to symptoms such as fatigue, weakness, hypotension, and electrolyte imbalances. Cushing syndrome (A) is a condition caused by excess glucocorticoid production or administration, diabetes insipidus (C) is a disorder of the pituitary gland or kidneys that affects water balance, and hypocalcemic tetany (B) is a condition characterized by low levels of calcium and manifests as muscle spasms and cramps.