How Does Curare Paralyze a Muscle

Question

How does curare paralyze a muscle?
A) Depletes the sarcomere of calcium
B) Blocks the prejunctional release of ACh
C) Blocks the postjunctional NM receptors
D) Degrades the cholinesterase within the NMJ

Accepted Answer

Curare blocks the postjunctional NM (neuromuscular) receptors, specifically the nicotinic acetylcholine receptors. This prevents the binding of acetylcholine and inhibits muscular contractions, ultimately leading to paralysis.