What is the Stimulus for the Release of ACh from the Prejunctional

Question

What is the stimulus for the release of ACh from the prejunctional membrane?
A) Acetylcholinesterase
B) Nerve action potential
C) Release of calcium by the SR
D) Muscle membrane electrical signal

Accepted Answer

The release of ACh from the prejunctional membrane is stimulated by a nerve action potential. When the nerve impulse reaches the terminal bouton, it causes the opening of voltage-gated calcium channels, leading to an influx of calcium into the presynaptic neuron. This influx of calcium triggers the release of ACh-containing vesicles into the synaptic cleft.